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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
10.91
Human Site:
S346
Identified Species:
18.46
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
S346
E
W
E
A
Q
R
D
S
H
L
G
P
H
R
S
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
P332
E
L
R
D
V
S
H
P
D
V
C
N
P
Q
W
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
E273
G
P
H
R
S
T
P
E
S
R
A
A
V
Q
E
Dog
Lupus familis
XP_547503
717
78133
A583
L
D
P
S
S
Q
G
A
L
Q
L
P
Y
D
P
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
S346
E
W
E
A
Q
R
D
S
H
L
G
P
H
R
S
Rat
Rattus norvegicus
P97887
468
52771
S347
E
W
E
A
Q
R
D
S
H
L
G
P
H
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
I344
S
I
P
P
Q
R
G
I
P
A
N
L
P
A
Y
Chicken
Gallus gallus
Q4JIM4
468
52812
N347
E
W
Q
Q
Q
R
D
N
R
I
G
P
I
E
S
Frog
Xenopus laevis
O12976
433
48282
E322
G
P
I
N
S
T
P
E
S
R
V
A
V
Q
A
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
Q339
Q
H
Q
L
G
P
M
Q
S
T
E
E
S
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
S367
S
G
Q
R
T
G
N
S
H
P
R
Q
N
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
E333
Q
N
S
G
V
R
V
E
R
E
L
A
A
E
R
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
R387
V
F
T
E
R
R
E
R
D
L
E
R
S
A
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
V339
D
E
E
M
S
P
L
V
E
L
M
G
W
G
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
6.6
0
6.6
N.A.
100
100
N.A.
13.3
53.3
0
6.6
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
20
6.6
33.3
N.A.
100
100
N.A.
13.3
73.3
13.3
20
N.A.
40
N.A.
13.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
0
0
0
8
0
8
8
22
8
15
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
8
8
0
8
0
0
29
0
15
0
0
0
0
8
8
% D
% Glu:
36
8
29
8
0
0
8
22
8
8
15
8
0
15
8
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
15
8
0
8
8
8
15
0
0
0
29
8
0
8
0
% G
% His:
0
8
8
0
0
0
8
0
29
0
0
0
22
0
0
% H
% Ile:
0
8
8
0
0
0
0
8
0
8
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
8
0
8
0
0
8
0
8
36
15
8
0
0
0
% L
% Met:
0
0
0
8
0
0
8
0
0
0
8
0
0
0
0
% M
% Asn:
0
8
0
8
0
0
8
8
0
0
8
8
8
0
8
% N
% Pro:
0
15
15
8
0
15
15
8
8
8
0
36
15
0
8
% P
% Gln:
15
0
22
8
36
8
0
8
0
8
0
8
0
29
0
% Q
% Arg:
0
0
8
15
8
50
0
8
15
15
8
8
0
29
22
% R
% Ser:
15
0
8
8
29
8
0
29
22
0
0
0
15
0
29
% S
% Thr:
0
0
8
0
8
15
0
0
0
8
0
0
0
0
0
% T
% Val:
8
0
0
0
15
0
8
8
0
8
8
0
15
0
0
% V
% Trp:
0
29
0
0
0
0
0
0
0
0
0
0
8
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _